发明名称 |
METALLOPROTEIN INHIBITORS |
摘要 |
The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, and R<SUP>4 </SUP>is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.
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申请公布号 |
US2007117848(A1) |
申请公布日期 |
2007.05.24 |
申请号 |
US20060554475 |
申请日期 |
2006.10.30 |
申请人 |
PUERTA DAVID T;COHEN SETH M;LEWIS JANA A |
发明人 |
PUERTA DAVID T.;COHEN SETH M.;LEWIS JANA A. |
分类号 |
A61K31/4439;A61K31/167;A61K31/35;A61K31/405;A61K31/435;A61K31/4412;C07D213/63;C07D213/69;C07D309/36;C07D309/38;C07D309/40 |
主分类号 |
A61K31/4439 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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