| 摘要 |
Provided are proteins having NF-kappaB activity, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of NF-kappaB. Using plasmid pNFkappaB-Luc, cDNA encoding a protein capable of activating NF-kappaB has been cloned from a cDNA library constructed from human lung fibroblasts, and the DNA sequence and the deduced amino acid sequence determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transforrnant containing the recombinant vector are useful for screening a substance inhibiting or promoting NF-kappaB activation.
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