A METHOD FOR IDENTIFYING AN AGENT THAT MODULATES ARGININE TRANSPORT IN A CHONDROCYTE
摘要
The present invention relates to an assay method for identifying an agent that modulates arginine transport in a chondrocyte comprising the steps of: (a) identifying an agent that modulates the activity and/or expression of CAT-2; and (b) measuring arginine transport in the chondrocyte in the presence or absence of said agent, wherein a difference between: (a) arginine transport in the absence of the agent; and (b) arginine transport in the presence of the agent is indicative that the agent can modulate arginine transport in a chondrocyte. Therapeutic agents that modulate the expression or activity of CAT-2B could be beneficial for the treatment of inflammatory diseases, particularly osteoarthritis. For example, a CAT-2B antagonist may be useful for the treatment of osteoarthritis.
申请公布号
WO2007032717(A8)
申请公布日期
2007.05.10
申请号
WO2006SE00923
申请日期
2006.07.31
申请人
ASTRAZENECA AB;BELFIELD, GRAHAM;DELANEY, STEPHEN;RAWLINS, PHILIP