MICE EXPRESSING AN IMMUNOGLOBULIN HYBRID LIGHT CHAIN
摘要
A transgenic mouse is provided comprising in its genome an endogenous » light chain immunoglobulin locus comprising a deletion of the endogenous mouse V»1-J»3-C»3-J»1-C»1 gene cluster and a deletion of a region spanning from V»2 to J»2 of the endogenous mouse V»2-V»3-J»2-C»2-J»4-C»4 gene cluster. Mouse cells and mouse embryos are also provided.
申请公布号
HRP20160497(T1)
申请公布日期
2016.07.15
申请号
HR2016P000497T
申请日期
2016.05.10
申请人
REGENERON PHARMACEUTICALS, INC.
发明人
MacDonald, Lynn;Stevens, Sean;Gurer, Cagan;Murphy, Andrew J.;Hosiawa, Karolina A.
