CARZOLE SULPHAMIDE DERIVATIVES AND THEIR PREPARATION METHOD

摘要

The present application has disclosed carzole sulphamide derivatives and their pharmaceutically acceptable salts of formula (I). The compounds can be used as small molecular anti-mitotic agent. The compounds not only can inhibit tumor cell in the first mitosis, but also have remarkable antitumor activity. They have the advantage of small molecular and simple synthesis without drug resistance problems. The present application also provides pharmaceutical composition containing the carzole sulphamide derivatives as active ingredient.