| 摘要 |
<p num="1"><br/><br/><br/>A system or method automates and optimizes citrate anticoagulant <br/>supplementation in a blood filtration circuit during CRRT. A processor-based <br/>control system interfaces with a blood filtration circuit to detect patient <br/>blood flow into the circuit, detect fluid loss through a hemofilter, and sense <br/>vital electrolyte concentrations in the blood flow, and in response, control <br/>the addition of citrate, substitution fluid, and electrolyte supplements to <br/>ensure stability of plasma concentrations in post-dilution flow returned to <br/>the patient. The controller executes the method embodied as process control <br/>algorithms for calculating an optimal citrate flow rate as a function of <br/>selected, detected, and calculated system parameters. Citrate may be added to <br/>the circuit separately, or as part of a substitution solution or a dialysate.<br/></p> |
