| 摘要 |
The derivatives of aryl(or heteroaryl)azolylcarbinol (I) wherein Ar is optionally substituted phenyl or thienyl, R1 is a hydrogen atom, a cyclohexyl group, N-methylpiperidyl group, phenyl group, vinyl group or C1-C4 alkyl group; R2 is H, dialkylaminoalkyl, alkylazaheterocycloalkyl or azaheterocyclylalkyl and Het is a nitrogenated aromatic heterocycle of 5 members which contains from 1 to 3 nitrogen atoms and is optionally substituted, are useful for the treatment of troubles which are mediated by an excess of substance P, specially certain troubles of the central nervous system such as anxiety, depression, schizophrenia, maniaco-depressive psychosis, sexual dysfunction, drug addiction, cognitive troubles, locomotion troubles, etc. in mammals, including human beings. |
