发明名称 Rationally designed polysaccharide lyases derived from chondroitinase B
摘要 The invention relates to rationally designed polysaccharide lyases and uses thereof. In particular, the invention relates to modified chondroitinase B. The modified chondroitinase B enzymes of the invention are useful for a variety of purposes, including cleaving and sequencing polysaccharides such as glycosaminoglycans (GAGs) as well as removing polysaccharides from a solution. The invention also includes methods of inhibiting anticoagulant activity, inhibiting angiogenesis, treating cancer, and inhibiting maternal malarial infection.
申请公布号 US2007065424(A1) 申请公布日期 2007.03.22
申请号 US20060518389 申请日期 2006.09.08
申请人 发明人 POJASEK KEVIN;RAMAN RAHUL;SASISEKHARAN RAM
分类号 A61K38/47;C07H21/04;C08B37/00;C12N1/21;C12N9/24;C12N15/74;C12P21/06;C12Q1/34 主分类号 A61K38/47
代理机构 代理人
主权项
地址