| 摘要 |
Specified phenylpropionic acid derivatives and analogues thereof have an antagonistic activity to alpha 4 integrin. They are used as therapeutic agents or preventive agents for various diseases concerning alpha 4 integrin, such as inflammatory diseases in which alpha 4 integrin-depending adhesion process participates in the pathology, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.
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