发明名称 |
ANTIBODIES AND THEIR USE IN THE TREATMENT, PREVENTION AND DIAGNOSIS OF A DISEASE ASSOCIATED WITH SOD1 ABNORMALITIES |
摘要 |
The present invention concerns an antibody which specifically binds to an abnormal superoxide dismutase 1 (SOD1), and which neutralizes its pathologic effect when administered to an animal such as a human. The antibody of the invention is a monoclonal antibody produced by hybridoma cell lines deposited with the International Depositary Authority of Canada on August 29th, 2006 under accession numbers ADI-290806-01 , ADI-290806-02 and ADI-290806-03. The present invention also concerns the use of the antibody of the invention in the treatment, prevention and diagnosis of neurodegenerative diseases such as Amyotrophic lateral sclerosis, Parkinson and Alzheimer in an animal such as a human. |
申请公布号 |
WO2007025385(A1) |
申请公布日期 |
2007.03.08 |
申请号 |
WO2006CA01444 |
申请日期 |
2006.08.31 |
申请人 |
UNIVERSITE LAVAL;JULIEN, JEAN-PIERRE;URUSHITANI, MAKOTO |
发明人 |
JULIEN, JEAN-PIERRE;URUSHITANI, MAKOTO |
分类号 |
C12P21/08;A61K39/395;A61P25/28;C07K16/40;C12N5/18;C12N9/04;C12N15/53;G01N33/53 |
主分类号 |
C12P21/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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