SUBSTITUTED PHENOXAZINES AND ACRIDONES AS INHIBITORS OF AKT

摘要

The invention provides compositions and methods that modulate the activity of AKT family kinase proteins, including AKTl, AKT2 and AKT3 (also referred to as PKBa, PKBß and PKB?). Specifically, the invention provides a number of phenoxazine and acridone compounds that inhibit AKT phosphorylation and kinase activity. The invention provides compositions for and methods of modulating AKT activity, inhibiting cell growth, treating cancer, treating transplant rejection, and treating coronary artery disease based upon the phenoxazine and acridone compounds of the invention.