发明名称 |
PROCESS FOR PREPARING R-2-ACYLOXY-1-ARYLPROPANONE AND S-2-HYDROXY-1-ARYLPROPANONE DERIVATIVE FROM 2-HYDROXY-1-ARYLPROPANONE BY USING LIPASE |
摘要 |
Provided is a process for preparing R-2-acyloxy-1-arylpropane derivative and S-2-hydroxy-1-arylpropanone derivative having a high optical purity from a racemic 2-hydroxy-1-arylpropanone derivative with a high yield in an industrial scale. The process for preparing an S-2-hydroxy-1-arylpropanone derivative represented by a formula 2 and an R-2-acyloxy-1-arylpropane derivative represented by a formula 3 comprises a step of acylating a racemic 2-hydroxy-1-arylpropanone represented by a formula 1 in the presence of a lipase catalyst derived from candida antartica by using an acyl donating agent. In formulae 1-3, X is H or Cln, Brn, Fn, acyl, alkyl, nitro or a combination thereof (n is 1 or 2); and R is a C1-C10 saturated or unsaturated alkyl group.
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申请公布号 |
KR100688905(B1) |
申请公布日期 |
2007.02.23 |
申请号 |
KR20050080097 |
申请日期 |
2005.08.30 |
申请人 |
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY |
发明人 |
KIM, BUM TAE;LEE, YEON SOO;MIN, YONG KI;HEO, JUNG NYOUNG;LEE, HYUK;PARK, NO KYUN |
分类号 |
C07C45/61;C12P41/00 |
主分类号 |
C07C45/61 |
代理机构 |
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