| 发明名称 |
BIOSYNTHETIC GENE CLUSTER FOR THE PRODUCTION OF A COMPLEX POLYKETIDE. |
| 摘要 |
<p>A polyketide synthase complex composed of polyketide synthase with 15 total modules, a non-ribosomal peptide synthetase with I module, and a cytochrome P450 hydroxylase is described. Also provided are novel Streptomyces species and methods of modified Streptomyces species. Further described are novel compounds, 36-ketomeridamycin, C9-deoxomeridamycin, and C9-deoxoprolylmeridamcyin and uses thereof.</p> |
| 申请公布号 |
MXPA06014080(A) |
申请公布日期 |
2007.02.15 |
| 申请号 |
MX2006PA14080 |
申请日期 |
2005.06.03 |
| 申请人 |
WYETH. |
发明人 |
PONG, KEVIN;HE, MIN;HUCUL, JOHN;HALTLI, BRADLEY ARNOLD;WAGENAAR, MELISSA M.;GRAZIANI, EDMUND;SUMMERS, MIA;KULOWSKI, KERRY;FENG, XIDONG |
| 分类号 |
C07D498/18;A61K31/407;A61K31/4745;C07D491/14;C07D498/08;C07H21/04;C12N1/21;C12N9/00;C12N9/10;C12N15/52;C12P17/16;C12P17/18;C12P19/62 |
主分类号 |
C07D498/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
