| 摘要 |
FIELD: medicine. ^ SUBSTANCE: invention relates to method for production of neuromuscular relaxant drug for treatment of muscle dystonias, such as blepharospasm, hemifascial spasm, incominant strabismus, distonic torticollis, local muscle spasm in adults. Claimed method includes culturing of Clostridium botulinum strain 501 on nutrient medium, microbial mass separation by microfiltration, purification by gel-permeation chromatography on column filled with sepharose sorption of diethylaminoethyl cellulose, combining with cryoprotectors , followed by sterilization and lyophilization. ^ EFFECT: simplified method for production of neuromuscular relaxant drug. ^ 1 ex, 1 dwg |
