METHOD FOR DIAGNOSIS OF GASTRIC CANCER UTILIZING METHYLATION OF NOVEL GENE ACMG1 AS INDEX

摘要

It is found that the abnormal methylation of CpG island in an ACMG1 gene is observed with a high frequency and that the expression of the gene is suppressed in a gastric cancer cell strain. Thus, disclosed is a method for detecting gastric cancer by determining the frequency of the methylation of an ACMG1 gene in a sample collected from a subject. Also disclosed is a method for screening a candidate substance as a therapeutic agent for gastric cancer by utilizing the suppression of the methylation of an ACMG1 gene or the promotion of the expression of an ACMG1 gene as an index.