A PROCESS FOR THE PREPARATION OF RUPATADINE

摘要

Rupatadine is synthesized by phase transfer catalysed N-alkylation of Desloratadine in biphasic solvent system using aqueous alkali by reaction of a compound of formula (A), X= leaving group as -OH -OTs, OMs -OAc -OAr -Br -Cl, -l with Desloratadine at temperature up to 50°C , wherein solvent selected is water immiscible organic solvent. Rupatadine is further converted to Rupatadine fumarate by reaction of Rupatadine in ketonic solvent with an alcoholic solution of fumaric acid.