IDENTIFICATION OF A NOVEL BITTER TASTE RECEPTOR T2R76 THAT SPECIFICALLY RESPONDS TO BRUCINE AND PROP BITTER LIGANDS

摘要

Isolated nucleic acids encoding T2R76 polypeptides, recombinants expressed T2R76 polypeptides, heterologous expression systems for recombinant expression of T2R76 polypeptides, assay methods employing the same, and methods for altering taste perception via administration of a T2R76 modulator. These T22R76 polypeptides can be expressed alone or co-expressed with another T2R polypeptide, preferably a different human T2R polypeptide. These T2R76 polypeptides specifcally respond to bitter ligands including brucine and propylthiouracil (PROP) and therefore can be used in assays that identify compounds that modulate, preferably block bitter taste.