发明名称 |
METHODS AND COMPOSITIONS FOR ENHANCING DEVELOPMENTAL POTENTIAL OF OOCYTES AND PREIMPLANTATION EMBRYOS |
摘要 |
The invention is directed to compositions and methods for enhancing the developmental potential of oocytes or preimplantation embryos by modulating mitochondrial-associated proteins and/or genomic integrity modifier proteins in oocytes or preimplantation embryos. Preferred embodiments for the mitochondrial-associated proteins are members of the Bcl-2 family of protein s. RecA family proteins, including Rad51 are preferred for the genomic integrit y modifier proteins. In one aspect of the invention, the levels of one or more mitochondrial-associated proteins and/or genomic integrity modifier proteins are increased, in particular by introducing the mitochondrial-associated proteins and/or genomic integrity modifier proteins into the oocytes or preimplantation embryos. Oocytes may be fertilized to obtain a zygote with increased levels of one or more mitochondrial-associated proteins and/or genomic integrity modifier proteins. The methods and compositions may be use d to improve in vitro fertilization and embryo transfer methods, and nuclear transfer techniques. |
申请公布号 |
CA2612191(A1) |
申请公布日期 |
2007.01.11 |
申请号 |
CA20062612191 |
申请日期 |
2006.06.16 |
申请人 |
MOUNT SINAI HOSPITAL;GENERAL HOSPITAL CORPORATION;BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY |
发明人 |
PEREZ, GLORIA I.;CASPER, ROBERT;JURISICOVA, ANDREA |
分类号 |
A61K38/17;A61D19/00 |
主分类号 |
A61K38/17 |
代理机构 |
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