RXR HOMODIMER FORMATION, BRIDGED BICYCLIC AROMATIC COMPOUND, AND THEIR USE IN MODULATED GENE EXPRESSION

摘要

PROBLEM TO BE SOLVED: To provide a method for screening a substance for the ability to exert an influence on the formation of a retinoid X receptor homodimer comprising a step for combining the substance and a solution containing retinoid X receptors and a step for determining the presence of homodimer formation. SOLUTION: The method for screening a substance for the ability to exert an influence on the formation of a retinoid X receptor homodimer comprises a step to combine the substance and a solution containing retinoid X receptors and a step to determine the presence of homodimer formation, and includes a step to determine the presence of the homodimer formation by detecting the activation of transcription by the retinoid X receptor homodimer. COPYRIGHT: (C)2007,JPO&INPIT