PLATINUM COMPLEXES WITH MONONITRILE-CONTAINING LIGANDS

摘要

Disclosed herein are novel platinum-based complexes possessing one nitrile substituent group (mononitrile) covalently-bonded to the platinum, one or mo re nitrogen donor ligands capable of forming hydrogen bonds with the bases in D NA or RNA and leaving groups (i.e., L1 and L2 )which can be hydrolyzed in vivo to active species, which can then form coordinate adducts with DNA or RNA at th e Guanine or Adenine bases thereof. Also disclosed herein are the reaction schemes for the synthesis of said platinum complexes, as well as methods of treatment of various types of cancer by the administration of a pharmaceutically-effective dose of said novel platinum complexes.