发明名称 |
Modified DNA molecule, recombinant containing the same, and uses thereof |
摘要 |
<p>There is provided a DNA molecule derived from a prokaryotic cell in which at least one of the DNA regions encoding NXB (N is asparagine, X is any amino acid other than proline, and B is serine or threonine) has been modified so that no N-glycosylation occurs during the expression in a eukaryotic cell, and since the DNA molecule has been modified at the N-glycosylation site, it produces a non-N-glycosylated protein, which thereby exhibits a high immunogenicity when, for example, it is allowed to produce, in a eukaryotic cell, an antigen protein derived from a prokaryotic cell.</p> |
申请公布号 |
EP1741720(A1) |
申请公布日期 |
2007.01.10 |
申请号 |
EP20060119421 |
申请日期 |
2002.07.11 |
申请人 |
ZEON CORPORATION |
发明人 |
OKUDA, TAKASHI;SAITO, SHUJI;DORSEY, KRISTI M.;TSUZAKI, YOSHINARI |
分类号 |
C07K14/30;C12N15/09;A61K35/76;A61K39/02;A61K39/04;A61K39/12;A61K39/245;A61K39/275;A61P31/12;A61P31/22;C07K14/005;C07K14/055;C12N1/21;C12N7/00;C12N7/01;C12N15/863 |
主分类号 |
C07K14/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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