发明名称 |
MUTATIONS IN NOD2 ARE ASSOCIATED WITH FIBROSTENOSING DISEASE IN PATIENTS WITH CROHN'S DISEASE |
摘要 |
The present invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease characterized by fibrostenosing disease by determining the presence or absence in an individual of a fibrostenosis-predisposing allele linked to a NOD2/CARD15 locus, where the presence of the fibrostenosis-predisposing allele is diagnostic of or predictive of susceptibility to the clinical subtype of Crohn's disease characterized by fibrostenosing disease. In a method of the invention, the clinical subtype of Crohn's disease can be, for example, characterized by fibrostenosing disease independent of small bowel involvement. The invention also provides a method of optimizing therapy in an individual by determining the presence or absence in the individual of a fibrostenosis-predisposing allele linked to a NOD2/CARD15 locus, diagnosing individuals in which the fibrostenosis-predisposing allele is present as having a fibrostenosing subtype of Crohn's disease, and treating the individual having a fibrostenosing subtype of Crohn's disease based on the diagnosis. |
申请公布号 |
EP1556405(A4) |
申请公布日期 |
2007.01.10 |
申请号 |
EP20030791618 |
申请日期 |
2003.07.30 |
申请人 |
CEDARS-SINAI MEDICAL CENTER |
发明人 |
ABREU, MARIA, T.;TAYLOR, KENT, D.;ROTTER, JEROME, I.;YANG, HUIYING;SUGIMURA, KAZUHITO;TARGAN, STEPHAN, R. |
分类号 |
C07H21/04;C12Q1/68;G01N;(IPC1-7):C07H21/04 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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