发明名称 Fumaric acid amides
摘要 Fumaric acid amides of the general formula (I) wherein R<SUP>1 </SUP>represents OR<SUP>3 </SUP>or a D- or L-amino acid radical -NH-CHR<SUP>4</SUP>-COOH bonded via an amide bond, wherein R<SUP>3 </SUP>is hydrogen, a straight-chained or branched, optionally substituted C<SUB>1-24 </SUB>alkyl radical, a phenyl radical or C<SUB>6-10 </SUB>aralkyl radical and R<SUP>4 </SUP>is a side chain of a natural or synthetic amino acid and R<SUP>2 </SUP>represents a D- or L-amino acid radical -NH-CHR<SUP>5</SUP>-COOH bonded via an amide bond or a peptide radical comprising 2 to 100 amino acids bonded via an amide bond, wherein R<SUP>5 </SUP>is a side chain of a natural or synthetic amino acid, are used for preparing a drug (1) for the therapy of an autoimmune disease; (2) for use in transplantation medicine; (3) for the therapy of mitochondrial diseases; or (4) for the therapy of NF-kappaB mediated diseases.
申请公布号 US7157423(B2) 申请公布日期 2007.01.02
申请号 US20030433295 申请日期 2003.06.02
申请人 FUMAPHARM AG 发明人 JOSHI RAJENDRA KUMAR;STREBEL HANS-PETER
分类号 A61K38/00;A61K38/11;A61K31/00;A61K31/16;A61K31/194;A61K31/198;A61K31/225;A61K38/02;A61K38/08;A61P1/00;A61P1/04;A61P1/16;A61P3/10;A61P9/00;A61P9/14;A61P11/00;A61P13/12;A61P17/00;A61P19/02;A61P19/06;A61P25/00;A61P25/14;A61P25/16;A61P25/28;A61P31/00;A61P31/04;A61P31/12;A61P35/00;A61P37/02;C07C235/76;C07K1/107;C07K2/00;C07K7/04;C07K7/64;C07K14/00 主分类号 A61K38/00
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