2-AMINO-4,5-TRISUBSTITUTED THIAZOLYL DERIVATIVES

摘要

The invention concerns the use of a compound of formula (I'), where the compound is a composition of the formulaa N - oxid, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof,whereinZ is halo; Calkyl; Calkylcarbonyl; Calkyloxycarbonyl; aminocarbonyl; Calkyl substituted with hydroxy, carboxyl, cyano, amino, amino substituted with piperidinyl, amino substituted with Calkyl substituted piperidinyl, mono -or di(Calkyl)amino, aminocarbonyl, mono -or di(Calkyl)aminocarbonyl, Calkyloxycarbonyl, Calkyloxy, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl; polyhalo Calkyl; cyano; amino; mono -or di(Calkyl)aminocarbonyl; Calkyloxycarbonyl; Calkylcarbonyloxy; amino-S(=O)-; mono -or di(Calkyl) amino-S(=O)or -C(=N-R)NRR;Ris hydrogen, Calkyl, cyano, nitro or-S(=O)-NH;Ris hydrogen, Calkyl, Calkenyl or Calkynyl;Ris hydrogen or Calkyl;Q is benzthiazolyl, pyridyl substituted with halo or Calkyl; phenyl or phenyl substituted with up to three substituents selected from halo, Calkyl, polyhalo- Calkyl, Calkyl Calkyloxycarbonyl, hydroxy, Calkyloxy, Calkylthio, 1-methyl-2-imidazolyl;L is pyridyl; pyridyl substituted with amino; 3-halophenyl; imidazopyridyl; imidazothiazolyl; pyrimidinyl, furalyl for the manufacture of a medicament for the prevention or the treatment of inflammatory and/or auto-immune diseases mediated through TNF- alpha and/or IL-12.