| 发明名称 |
PHENYL-SUBSTITUTED PYRIMIDINE COMPOUNDS USEFUL AS KINASE INHIBITORS |
| 摘要 |
Compounds having the formula (I), and pharmaceutically acceptable salts, and solvates thereof, are useful as kinase inhibitors, wherein: two of X<SUB>1</SUB>, X<SUB>2</SUB>, and X<SUB>3</SUB> are N, and the remaining one of X<SUB>1</SUB>, X<SUB>2</SUB>, and X<SUB>3</SUB> is -CR<SUB>1</SUB>; R<SUB>1</SUB> is hydrogen or -CN; and N, G, Z, R<SUB>2</SUB>, R<SUB>3</SUB>, R<SUB>4</SUB>, R<SUB>5</SUB>, and R<SUB>6</SUB> are described in the specification. Also disclosed are pharmaceutical compositions containing compounds of formula (I), and methods of treating conditions associated with the activity of p38 kinase and/or conditions associated with the activity of LIM kinase. |
| 申请公布号 |
WO2006084017(A3) |
申请公布日期 |
2006.12.14 |
| 申请号 |
WO2006US03659 |
申请日期 |
2006.02.02 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY;WROBLESKI, STEPHEN, T.;LIN, SHUQUN;LEFTHERIS, KATERINA;HE, LIQI;SEITZ, STEVEN, P.;LIN, TAI-AN;VACCARO, WAYNE |
发明人 |
WROBLESKI, STEPHEN, T.;LIN, SHUQUN;LEFTHERIS, KATERINA;HE, LIQI;SEITZ, STEVEN, P.;LIN, TAI-AN;VACCARO, WAYNE |
| 分类号 |
C07D417/04;A61P29/00;A61P35/00;C07D401/04;C07D417/14 |
主分类号 |
C07D417/04 |
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