发明名称 |
ErbB3 antibodies |
摘要 |
<p>Antibodies are disclosed which bind to ErbB3 protein and further possess any one or more of the following properties: an ability to reduce heregulin-induced formation of an ErbB2-ErbB3 protein complex in a cell which expresses ErbB2 and ErbB3; the ability to increase the binding affinity of heregulin for ErbB3 protein; and the characteristic of reducing heregulin-induced ErbB2 activation in a cell which expresses ErbB2 and ErbB3.</p> |
申请公布号 |
EP1728802(A3) |
申请公布日期 |
2006.12.13 |
申请号 |
EP20060014174 |
申请日期 |
1997.03.07 |
申请人 |
GENENTECH, INC. |
发明人 |
AKITA, ROBERT;SLIWKOWSKI, MARK |
分类号 |
C07K16/32;C12N15/02;A61K31/00;A61K38/00;A61K39/395;A61P35/00;A61P43/00;C07K16/28;C07K16/46;C07K17/00;C12N5/10;C12N5/20;C12N15/13;C12N15/64;C12P21/08;G01N33/574;G01N33/577 |
主分类号 |
C07K16/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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