发明名称 |
PROCESS FOR PREPARATION OF ISOTONIC AQUEOUS INJECTION OF ROPIVACAINE |
摘要 |
The preparation of an injectable solution of ropivacaine by dissolving ropivacaine base in aqueous acidic solution having a molar ratio of acid to ropivacaine base greater than 1:1 eliminates the need for a hydrochloride or hydrochloride monohydrate intermediate in the manufacture of the injectable. The osmolality can be adjusted as needed. The excess acid is neutralized wit h a base.
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申请公布号 |
CA2608730(A1) |
申请公布日期 |
2006.11.30 |
申请号 |
CA20062608730 |
申请日期 |
2006.05.22 |
申请人 |
NAVINTA LLC |
发明人 |
JOBDEVAIRAKKAM, CHRISTOPHER N.;RANGISETTY, JAGADEESH B. |
分类号 |
A61K9/10;A61P23/02 |
主分类号 |
A61K9/10 |
代理机构 |
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