Methanocarba cycloalkyl nucleoside analogues

摘要

The present invention provides novel nucleoside and nucleotide derivatives that are useful agonist or antagonists of P1 and P2 receptors. For example, the present invention provides a compound of formula A-M, wherein A is modified adenine or uracil and M is a constrained cycloalkyl group. The adenine or uracil is bonded to the constrained cycloalkyl group. The compounds of the present invention are useful in the treatment or prevention of various diseases including airway diseases (through A_2B, A₃, P2Y₂ receptors), cancer (through A₃, P2 receptors), cardiac arrhythmias (through A1 receptors), cardiac ischemia (through A₁, A₃ receptors), epilepsy (through A1, P2X receptors), and Huntington's Disease (through A_2A receptors).