| 发明名称 |
INHIBITORS OF C-AMP PHOSPHODIESTERASE AND TNF |
| 摘要 |
This invention is directed to the pharmaceutical use of phenyl compound s, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation a nd pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase. Compounds according to the invention are of formula I which has the following general chemical structure: |
| 申请公布号 |
CA2140441(C) |
申请公布日期 |
2006.11.21 |
| 申请号 |
CA19932140441 |
申请日期 |
1993.07.28 |
| 申请人 |
RHONE-POULENC RORER LIMITED |
发明人 |
FENTON, GARRY;MORLEY, ANDREW DAVID;PALFREYMAN, MALCOLM NORMAN;RATCLIFFE, ANDREW JAMES;SHARP, BRIAN WILLIAM;STUTTLE, KEITH ALFRED JAMES;THURAIRATNAM, SUKANTHINI;VACHER, BERNARD YVON JACK |
| 分类号 |
C07D213/72;C07D239/34;A61K31/00;A61K31/425;A61K31/44;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/4418;A61K31/4433;A61K31/505;A61P1/00;A61P7/00;A61P11/00;A61P13/02;A61P15/00;A61P29/00;A61P43/00;C07C43/205;C07C43/21;C07C43/215;C07C43/225;C07C43/243;C07C43/247;C07C45/00;C07C45/29;C07C45/71;C07C47/575;C07C49/84;C07C59/58;C07C59/60;C07C59/62;C07C65/21;C07C65/24;C07C65/42;C07C69/76;C07C69/773;C07C69/92;C07C69/94;C07C205/59;C07C205/60;C07C217/58;C07C217/88;C07C233/67;C07C233/75;C07C235/56;C07C245/20;C07C255/60;C07C275/34;C07C311/21;C07C311/29;C07C311/46;C07C317/14;C07C317/40;C07C321/24;C07C323/17;C07C323/31;C07C323/42;C07C323/65;C07C323/66;C07C323/67;C07C327/48;C07D213/50;C07D213/61;C07D213/75;C07D213/89;C07D239/38;C07D239/42;C07D241/18;C07D241/20;C07D261/14;C07D275/02;C07D275/03;C07D409/12 |
主分类号 |
C07D213/72 |
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