PROCESS FOR PRODUCING BICALUTAMIDE AND METHOD OF PURIFYING INTERMEDIATE THEREFOR

摘要

A process for producing bicalutamide, which is represented by the formula (4), (4) which comprises: a step (A) in which the compound represented by the formula (1) is reacted with a peroxycarboxylic acid to obtain the compound (2) represented by the formula (2); (2) a step (B) in which the compound (2) is reacted with 4-fluorothiophenol to obtain crude crystals of the compound (3) represented by the formula (3) and the crude crystals are dissolved in a solvent and crystallized therefrom to obtain purified crystals of the compound (3); and a step (C) in which the purified crystals of the compound (3) are reacted with a peroxycarboxylic acid to obtain bicalutamide. Also provided is a method of purifying crystals of the compound (3), which comprises dissolving crude crystals of the compound (3) in a solvent and crystallizing it.