发明名称 |
PROCESS FOR PRODUCING 4-AMINO-2-ALKYLTHIO-5-PYRIMIDINECARBALDEHYDE |
摘要 |
<p>An industrially advantageous process for 4-amino-2-alkylthio-5-pyrimidinecarbaldehyde production by which a 4-amino-2-alkylthio-5-pyrimidinecarbaldehyde can be easily produced in a high yield; an intermediate compound for use in the process; and an industrially advantageous production process by which the intermediate compound can be easily and safely produced in a high yield. A process for producing an alkali metal salt of a 3,3-dialkoxy-2-hydroxymethylenepropanenitrile is provided which is characterized by reacting at least one nitrile compound selected from the group consisting of 3,3-dialkoxypropanenitriles and 3-alkoxy-2-propenenitriles with a formic ester at -10 to 30°C in the presence of a base containing an alkali metal. Also provided are: an alkali metal salt of 4-amino-2-mercapto-5-pyrimidinecarbaldehyde; a process for producing the alkali metal salt of 4-amino-2-mercapto-5-pyrimidinecarbaldehyde which is characterized by reacting the 3,3-dialkoxy-2-hydroxymethylenepropanenitrile alkali metal salt with thiourea; a process for producing a 4-amino-2-alkylthio-5-pyrmidinecarbaldehyde which is characterized by reacting the 4-amino-2-mercapto-5-pyrmidinecarbaldehyde alkali metal salt with an alkylating agent; and a use of the 4-amino-2-mercapto-5-pyrimidinecarbaldehyde alkali metal salt in producing the 4-amino-2-alkylthio-5-pyrimidinecarbaldehyde.</p> |
申请公布号 |
WO2006115237(A1) |
申请公布日期 |
2006.11.02 |
申请号 |
WO2006JP308507 |
申请日期 |
2006.04.24 |
申请人 |
UBE INDUSTRIES, LTD.;NISHINO, SHIGEYOSHI;SHIKITA, SHOJI;MURAKAMI, TADASHI |
发明人 |
NISHINO, SHIGEYOSHI;SHIKITA, SHOJI;MURAKAMI, TADASHI |
分类号 |
C07C253/30;C07C255/15;C07D239/47 |
主分类号 |
C07C253/30 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|