发明名称 |
COMPOSITIONS OF ESTROGEN-CYCLODEXTRIN COMPLEXES |
摘要 |
Pharmaceutical compositions comprising low doses of sensitive complexes between an estrogen and a cyclodextrin are provided with improved stability. In specific embodiments the composition comprises a complex between ethinyl estradiol and &bgr;-cyclodextrin in a granulate preparation and in yet another embodiment the composition comprises a limited amount of polyvinylpyrrolidone since this excipient was found to degrade ethinyl estradiol. Furthermore, a method for improving the stability of an estrogen in a composition and for manufacturing such a stable composition is provided. Essentially, the granulate preparation are manufactured under careful control of the relative humidity. |
申请公布号 |
EA007411(B1) |
申请公布日期 |
2006.10.27 |
申请号 |
EA20030000669 |
申请日期 |
2001.12.20 |
申请人 |
SCHERING AKTIENGESELLSCHAFT |
发明人 |
BACKENSFELD THOMAS;HEIL WOLFGANG;LIPP RALPH |
分类号 |
A61K47/32;A61K47/40;A61K9/16;A61K31/565;A61K31/566;A61K31/57;A61K31/585;A61K31/715;A61K31/724;A61K47/48;A61P5/30;A61P15/00;A61P15/18;C08B37/00 |
主分类号 |
A61K47/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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