发明名称 |
Nucleic acid array consisting of selective monocyte macrophage genes |
摘要 |
The invention relates to an array comprising oligo- or poly-nucleotide probes, immobilized on a solid support. The array is characterized in that, sequences of a selection or all of the selective monocytic macrophagic genes given in Tables 1-6 are bonded on the surface. The array permits the diagnosis of rheumatoid arthritis and other chronic inflammatory diseases, a corresponding analysis of the efficacy of treatment and the monitoring of side-effects with the anti-tumor necrosis factor (TNF) therapy and thus permits the selection of the most effective therapy for each patient with rheumatoid arthritis. The invention further relates to a nucleic acid array for the prognosis and development of novel anti-TNF type medicaments and such medicaments with a mode of action in said regulatory circuit.
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申请公布号 |
US2006216707(A1) |
申请公布日期 |
2006.09.28 |
申请号 |
US20050521935 |
申请日期 |
2005.01.24 |
申请人 |
STUHLMULLER BRUNO;HAEUPL THOMAS;KIESSLICH OLAF;BURMESTER GERD-RUDIGER |
发明人 |
STUHLMULLER BRUNO;HAEUPL THOMAS;KIESSLICH OLAF;BURMESTER GERD-RUDIGER |
分类号 |
C12Q1/68;C12M1/34 |
主分类号 |
C12Q1/68 |
代理机构 |
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地址 |
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