发明名称 |
Process for the preparation of high purity perindopril and intermediates useful in the synthesis |
摘要 |
The invention relates to 1-ä2(S)-Ä1(S)-(ethoxycarbonyl)butylaminoÜpropionylü-(3aS,7aS)octahydro indol-2(S)-carboxylic acid of the Formula I and the t-butylamine salt of the Formula I' thereof free of contaminations derivable from dicyclohexyl carbodiimide, and a process for the preparation thereof. The invention also relates to new intermediates of the general Formula III (wherein R stands for lower alkyl or aryl lower alkyl). The compound of the Formula I - perindopril - is a known ACE inhibitor. |
申请公布号 |
ZA200405548(B) |
申请公布日期 |
2006.09.27 |
申请号 |
ZA20040005548 |
申请日期 |
2003.01.29 |
申请人 |
LES LABORATOIRES SERVIER |
发明人 |
GYULA SIMIG;TIBOR MEZEI;MARTA MPORCS-MAKKAY;ATTILA MANDI |
分类号 |
A61K31/404;A61K;A61P;A61P9/12;A61P43/00;C07C;C07D;C07D209/42 |
主分类号 |
A61K31/404 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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