| 摘要 |
<p>A process for the preparation of substituted benzothiazinoindoles of general formula (I) wherein R<SUB>1</SUB>, R<SUB>2</SUB>, and R<SUB>4</SUB> are independently selected from hydrogen, chloro, fluoro, amino, nitro, cyano, CHO, (C<SUB>1</SUB>-C<SUB>3</SUB>)alkyl, perhalo(C<SUB>l</SUB>-C<SUB>3</SUB>)alkyl, (C<SUB>1</SUB>-C<SUB>3</SUB>)alkoxy, aryl, aralkyl, aralkoxy, (C<SUB>5</SUB>-C<SUB>7</SUB>)heterocyclyl, (C<SUB>5</SUB>-C<SUB>7</SUB>)heterocyclylalkyl, (C<SUB>5</SUB>-C<SUB>7</SUB>)heterocyclyloxy, acyl, acetyl, alkylamino, aminoalkyl, amide, hydroxyalkyl, carboxylic acid and its derivatives, while R<SUB>3</SUB> is selected hydrogen, (C<SUB>1</SUB>-C<SUB>3</SUB>)alkyl, aryl and carboxylic acid and its derivatives is disclosed, said process comprising cyclization of compound of general formula-II, (i.e. substituted 1-benzenesulfonyl-7-bromo-lH-indole), formula (II) wherein R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>3</SUB> and R<SUB>4</SUB> using suitable catalyst and solvents wherein.</p> |
| 申请人 |
SUVEN LIFE SCIENCES LIMITED;RAMAKRISHNA, VENKATA, SATYA, NIROGI;SHIRSATH, VIKAS, SHREEKRISHNA;KAMBHAMPATI, RAMA, SASTRI;DESHPANDE, AMOL, DINKAR;KOTHMIRKAR, PRABHAKAR;JASTI, VENKATESWARLU |
发明人 |
RAMAKRISHNA, VENKATA, SATYA, NIROGI;SHIRSATH, VIKAS, SHREEKRISHNA;KAMBHAMPATI, RAMA, SASTRI;DESHPANDE, AMOL, DINKAR;KOTHMIRKAR, PRABHAKAR;JASTI, VENKATESWARLU |
