Novel aminopyridine compounds having Syk inhibitory activity

摘要

The present invention relates to an aminopyridine compound represented by the following general formula (I) or a salt thereof and an Syk inhibitor containing the compound or a salt thereof as an active ingredient. Here, X¹, X², X³, Z, Y¹, Y² represent a carbon atom or a nitrogen atom, R, R¹, R⁵, R⁶ represent a hydrogen atom, an alkyl group, etc., and R⁷ represents a hydrogen atom, a halogen atom, a nitro group, a cyano group, -C_pH_2(p-1)(R^a1)(R^a2)-O-R^a3, -C(-O)-R^d1, a 5- or 6-membered saturated heterocyclic group, an aromatic heterocyclic group, -N(R^h1)(R^h2), etc. The aminopyridine compound of the present invention has not only high Syk inhibitory activity but also properties to selectively inhibit Syk.