| 摘要 |
C-alkyl substituted e -caprolactams are produced by reacting an alkyl substituted cyclohexane carboxylic acid or a functional derivative thereof with 0.5 to 0.9. moles of a nitrosylating agent at a temperature below 100 DEG C. in the presence of fuming sulphuric acid and an inert diluent boiling at about the reaction temperature, the nitrosylating agent being added to the alkyl substituted cyclohexane carboxylic acid at such a rate that it is substantially consumed immediately on addition thereto. The reaction may be performed at 80 DEG C. The alkyl substituted cyclohexane carboxylic acid may be 4-methyl cyclohexane carboxylic acid, and the inert diluent is cyclohexane. The fuming sulphuric acid may contain from 10 to 20% excess sulphur trioxide and the nitrosylating agent may be nitrosyl sulphate or a compound forming it in the presence of fuming sulphuric acid. Other examples of reactants are given. The product may be recovered by neutralising the reaction mixture, diluting with water and then extracting with a solvent, e.g. chloroform. |
