HETEROALKYL AMINES AS GLYCOGEN SYNTHASE KINASE 3 BETA INHIBITORS (GSK3 INHIBITORS)

摘要

This invention concerns a compound of formula (I), a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein ring A is a 6-membered heterocycle; Ris hydrogen; aryl; formyl; Calkylcarbonyl; optionally substituted Calkyl; Calkyloxycarbonyl; optionally substituted Calkyloxy Calkylcarbonyl; X is a direct bond or a linker atom or group; Z is a direct bond or a linker atom or group; Ris hydrogen, Calkyl, Calkenyl, Calkynyl, a carbocycle or a heterocycle, each of said groups may optionally be substituted; Ris hydrogen; hydroxy; halo; optionally substituted Calkyl or Calkenyl or Calkynyl; Calkyloxy; Calkylthio; Calkyloxycarbonyl; Calkylcarbonyloxy; carboxyl; cyano; nitro; amino; mono- or di(Calkyl)amino; polyhalo Calkyl; polyhalo Calkyloxy; polyhalo Calkylthio; R; R- Calkyl; R-O-; R-S-; R-C(=O)-; R-S(=O)-; R-S (=O), R-S(=O)-NH-; R-S(=O)-NH-; R-C(=O)-; -NHC(=O)H; -C(=O)NHNH; R-C(=O)-NH-; R-C(=O)-NH-; -C(=NH)R; -C(=NH)R; Ris an optionally substituted heterocycle provided that -X-Rand/or Ris other than hydrogen; their use, pharmaceutical compositions comprising them and processes for their preparation.