METHODS OF IDENTIFYING GLUCOCORTICOIDS WITHOUT THE DETRIMENTAL SIDE EFFECTS OF BONE LOSS

摘要

The invention pertains to the elucidation of the pro-apoptotic effect of glucocorticoids on osteocytes. The present invention provides methods to screen compounds that retain the anti-inflammatory properties of glucocorticoids yet do not result in the detrimental effect of bone loss and compound identified by the methods.