Water-soluble phenylpyridazine compounds and compositions containing the same

摘要

Compounds having the formula (1): wherein R¹ represents an alkyl or alkenyl group, R² and R³ each independently represent a hydrogen atom or an alkyl, hydroxyalkyl, dihydroxyalkyl or alkynyl group, or R² and R³ may be fused together with the adjacent nitrogen atom to form a substituted or unsubstituted, nitrogen-containing, saturated heterocyclic group, X, Y and Z each independently represent a hydrogen atom, an alkyl group, a halogen atom or the like, and n stands for an integer of from 1 to 5; and also to medicinal compositions containing them. These compounds have inhibitory activity against IL-1beta production, high water solubility and good oral absorbability.