| 摘要 |
<p>The present invention relates to screening assays for the identification of agents that can inhibit expression of thioredoxin interacting protein (TXNIP). The use of such compounds, including the disclosed siRNA and antibodies against TXNIP, is contemplated for therapeutic or prophylactic treatment of vascular disease conditions, particularly those associated with pro-inflammatory activity of the TNF-ASK1-JNK-p38 pathways.</p> |
