YEAST TRANSFORMANT PRODUCING RECOMBINANT HUMAN PARATHYROID HORMONE AND METHOD FOR PRODUCING THE HORMONE
摘要
Novel Saccharomyces Cerevisiae mutant strains are provided for producing human parathyroid hormone. The novel strains acre genetically disrupted in at least one of the genes encoding the yapsin family of proteases Yapsin 1, Yapsin 2 and Yapsin 3 and harbor a human parathyroid hormone gene in their genomes. Culturing the novel strains results in the secretion of intact hPTH into culture media at high yield.
申请公布号
EP1313848(B1)
申请公布日期
2006.07.05
申请号
EP20010958618
申请日期
2001.08.27
申请人
DONG KOOK PHARMACEUTICAL CO., LTD.;KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
发明人
RHEE, SANG, KI;KANA, HYUN, AH;CHUNG, BONG, HYUN;KO, SU, MIN