METHODS FOR THE CONTROL, TREATMENT AND MANAGEMENT OF OBESITY

摘要

The present invention provides methods for the control of CNS disorders by modulating the extra-cellular concentration of endogenous cannabinoid and peptide hormone cell signalling molecules like ghrelins and Peptide YY (PYY). Derivatives of cell signalling molecules are conjugated to suitable carrier proteins and used to isolate high affinity receptors recognising the native signal molecules) from libraries of suitable receptors. By binding to signalling molecules, the receptors reduce available concentrations of signal molecules and modulate physiological responses controlled by them. Furthermore, the conjugates described herein have application as vaccines to stimulate anti-signal molecule immune responses in patients.