发明名称 |
FUNCTIONAL SYNTHETIC MOLECULES AND MACROMOLECULES FOR GENE DELIVERY |
摘要 |
The present invention describes a synthetic non-viral vector composition for gene therapy and the use of such compositions for in vitro, ex vivo and/or in vivo transfer of genetic material. The invention proposes a pharmaceutical composition containing 1) a non-cationic amphiphilic molecule or macromolecule and its use for delivery of nucleic acids or 2) a cationic amphiphilic molecule or macromolecule that transforms from a cationic entity to an anionic, neutral, or zwitterionic entity by a chemical, photochemical, or biological reaction and its use for delivery of nucleic acids. Moreover this invention describes the use of these non-viral vector compositions in conjunction with a surface to mediate the delivery of nucleic acids. An additional embodiment is the formation of a hydrogel with these compositions and the use of this hydrogel for the delivery of genetic material. A further embodiment of this invention is the use of a change in ionic strength for the delivery of genetic material. |
申请公布号 |
WO2005007810(A3) |
申请公布日期 |
2006.06.08 |
申请号 |
WO2004US19230 |
申请日期 |
2004.06.16 |
申请人 |
GRINSTAFF, MARK, W.;BARTHELEMY, PHILIPPE;PRATA, CARLA;MOREAU, LOUIS |
发明人 |
GRINSTAFF, MARK, W.;BARTHELEMY, PHILIPPE;PRATA, CARLA;MOREAU, LOUIS |
分类号 |
C07C69/00;C07C69/63;C07C219/06;C07C229/00;C07C233/36;C07C241/00;C07C271/22;C12N |
主分类号 |
C07C69/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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