| 发明名称 |
Site-directed modification of FVIII |
| 摘要 |
This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.
|
| 申请公布号 |
US2006115876(A1) |
申请公布日期 |
2006.06.01 |
| 申请号 |
US20050273896 |
申请日期 |
2005.11.14 |
| 申请人 |
BAYER HEALTHCARE LLC |
发明人 |
PAN CLARK Q.;MURPHY JOHN E.;MEI BAISONG;STRAUSS JONATHAN S.;TJANDRA HENDRI;CHEN JIANMIN;BARNETT THOMAS;TANG LIANG;WANG DEQIAN |
| 分类号 |
C12P21/06;C07H21/04;C07K14/745 |
主分类号 |
C12P21/06 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
