| 摘要 |
<p>A novel compound represented by the following formula (1) [wherein R<SUP>1</SUP>, R<SUP>5</SUP>, R<SUP>6</SUP>, R<SUP>7</SUP>, and R<SUP>8</SUP> each represents hydrogen, halogeno, hydroxy, alkyl, alkenyl, etc.; X<SUP>1</SUP>···X<SUP>2</SUP> represents -CH(R<SUP>2</SUP>)-CH(R<SUP>3</SUP>)-, -CH(R<SUP>2</SUP>)-CH(R<SUP>3</SUP>)-CH(R<SUP>4</SUP>)-, -C(R<SUP>2</SUP>)=C(R<SUP>3</SUP>)-, or -C(R<SUP>2</SUP>)=C(R<SUP>3</SUP>)-CH(R<SUP>4</SUP>)- (R<SUP>2</SUP>, R<SUP>3</SUP>, and R<SUP>4</SUP> each represents hydrogen or alkyl); A<SUP>1</SUP>, A<SUP>11</SUP>, A<SUP>2</SUP>, and A<SUP>21</SUP> each represents hydrogen or alkyl; Y represents -CH(A<SUP>3</SUP>)-, -CH(A<SUP>3</SUP>)-C(A<SUP>4</SUP>)(A<SUP>41</SUP>)-, -CH(A<SUP>3</SUP>)-C(A<SUP>4</SUP>)(A<SUP>41</SUP>)-C(A<SUP>5</SUP>)(A<SUP>51</SUP>)-, or a single bond (A<SUP>3</SUP>, A<SUP>4</SUP>, A<SUP>41</SUP>, A<SUP>5</SUP>, and A<SUP>51</SUP> each represents hydrogen or alkyl); and Z represents hydroxy or -N(A<SUP>6</SUP>)(A<SUP>61</SUP>) (A<SUP>6</SUP> represents hydrogen or alkyl and A<SUP>61</SUP> represents hydrogen, alkyl, substituted alkyl, etc.)] or a salt of the compound. The compound has the potent ability to inhibit the phosphorylation of a myosin light chain. [Chemical formula 1]</p> |
