| 摘要 |
One aspect of the present invention relates to a microsphere impregnated with a radioisotope that emits therapeutic ß-particles and a radioisotope that emits diagnostic gamma-radiation; wherein the atomic number of the first radioisotope is not the same as the atomic number of the second radioisotope. In one preferred embodiment, the microsphere is composed of glass impregnated with 90Y as the source of the therapeutic ß-emissions and 198Au as the source of the diagnostic gamma-emissions. Another aspect of the present invention relates to the preparation of a microsphere impregnated with a radioisotope that emits therapeutic ß-particles and a radioisotope that emits diagnostic gamma-radiation; wherein the atomic number of the first radioisotope is not the same as the atomic number of the second radioisotope. In one preferred embodiment, a glass microsphere containing 90Y and 198Au is prepared by neutron activation of a glass microsphere comprising glass, 89Y and 197Au. Another aspect of the present invention relates to administration to a mammal of a therapeutically effective amount of microspheres impregnated with a gamma-emitting radioisotope and a gamma-emitting radioisotope; wherein the atomic number of the first radioisotope is not the same as the atomic number of the second radioisotope. In one preferred embodiment, said microspheres are administered to the patient through a catheter. |
