CALML3 A SPECIFIC AND SENSITIVE TARGET FOR LUNG CANCER DIAGNOSIS, PROGNOSIS AND/OR THERANOSIS

摘要

The present invention relates in general to lung cancer and to the CALML3 gene. The present invention more specifically relates to methods of diagnosing lung cancer in a biological sample by detecting CALML3 nucleic acid or protein in the sample. In one particular embodiment, the invention relates to a method for diagnosing lung cancer in a human biological sample, the method comprising: analyzing the human biological sample for the presence of CALML3 polynucleotide, the detection of an elevated level of CALML3 indicating the presence of lung cancer, as compared to the level thereof in a normal human biological sample. In one embodiment, the biological sample is obtained by a non-invasive method. In yet another embodiment of the present invention the human biological sample is selected from a sputum, a bronchial aspirate, and a coughing sample. The present invention also relates to kits for diagnosing lung cancer.