2-(pyrazol-3-yl)carbapenem derivatives

摘要

A compound of formula (I): wherein R^alpha is hydrogen, optionally substituted (C_1-6)alkyl or optionally substituted aryl; R^beta is hydrogen, optionally substituted (C_1-6)alkyl or optionally substituted aryl; or R^alpha and R^beta together form an optionally substituted 5 or 6 membered heterocyclic ring with or without additional heteroatoms; R¹ is (C_1-6)alkyl which is unsubstituted or substituted by fluoro, a hydroxy group which is optionally protected by a removable hydroxy protecting group, or by an amino group which is optionally protected by a removable amino protecting group; R² is hydrogen or methyl; and -CO₂R³ is carboxy or a carboxylate anion or the group R³ is a removable carboxy protecting group. This invention also relates to processes for its preparation, intermediates and pharmaceutical compositions comprising compounds of formula (I). Compounds of formula (I) which include pharmaceutically acceptable salts or pharmaceutically acceptable in vivo hydrolysable esters thereof have a broad spectrum of anti-bacterial activity and show good stability towards DHP-1.