发明名称 |
Proteolysis targeting chimeric pharmaceutical |
摘要 |
The present invention is based on the discovery of a composition that provides targeted ubiquitination. Specifically the composition contains an ubiquitin pathway protein binding moiety which recognizes an ubiquitin pathway protein and a targeting moiety which recognizes a target protein. In addition, the present invention provides libraries of compositions, where each composition contains an ubiquitin pathway protein binding moiety and a member of a molecular library. The libraries of the present invention can be used to identify proteins involved in a predetermined function of cells.
|
申请公布号 |
US7041298(B2) |
申请公布日期 |
2006.05.09 |
申请号 |
US20010953473 |
申请日期 |
2001.09.10 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
DESHAIES RAYMOND J.;CREWS CRAIG;SAKAMOTO KATHLEEN M. |
分类号 |
A61K39/385;C07K14/47;C12N9/48;C12P21/06;G01N33/50 |
主分类号 |
A61K39/385 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|